Histone H2B type 1-M, Histone H2Be, H2B/e, HIST1H2BM, H2BFE
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP8780a was selected from the N-term region of human HIST1H2BM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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