PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this protein are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD).
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target:
The synthetic peptide sequence used to generate the antibody AP9276b was selected from the C-term region of human PHF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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