P21Cip1 Antibody Blocking peptide
Catalog Number:
ABT-BP9311A
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| Article Name: | P21Cip1 Antibody Blocking peptide |
| Biozol Catalog Number: | ABT-BP9311A |
| Supplier Catalog Number: | BP9311a |
| Alternative Catalog Number: | ABT-BP9311A-500UG |
| Manufacturer: | Abcepta |
| Category: | Proteine/Peptide |
| Alternative Names: | Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1 |
| This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. |
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