DIO3 Antibody (C-term) Blocking Peptide

Product Overview

• Article Name: DIO3 Antibody (C-term) Blocking Peptide
• Biozol Catalog Number: ABT-BP9529B
• Supplier Catalog Number: BP9529b
• Alternative Catalog Number: ABT-BP9529B-500UG
• Manufacturer: Abcepta
• Category: Proteine/Peptide
• Alternative Names: Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5-deiodinase, DIO3, ITDI3, TXDI3

Product Description

DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Product Properties

• NCBI: 1735
• UniProt: P55073
• Form: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.