SARS-CoV-2 Spike Peptide (TASALGKLQDVVNQN)
Catalog Number:
ABT-VGP1095
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| Article Name: | SARS-CoV-2 Spike Peptide (TASALGKLQDVVNQN) |
| Biozol Catalog Number: | ABT-VGP1095 |
| Supplier Catalog Number: | VGP1095 |
| Alternative Catalog Number: | ABT-VGP1095-100UG |
| Manufacturer: | Abcepta |
| Category: | Proteine/Peptide |
| Alternative Names: | E2, Peplomer, SARS-CoV-2 Spike Glycoprotein, sars-cov-2 |
| SARS-CoV-2 is part of the Coronaviridae family, whose members are named after their crown-like appearance under the electron microscope caused by the surface glycoproteins that decorate the virus. Coronaviruses have a large (30+ kb) single-stranded positivesense RNA genome encoding for several open reading frames. One frame encodes the spike protein (S protein), a class I fusion protein that mediates attachment of the virus to cell surface receptors followed by uptake into endosomes (for most coronaviruses). Proteolytic cleavage of the S protein and fusion of viral and endosomal membranes trigger release of viral RNA into the cytosol. We know now from studies on SARS-CoV-1 and the related MERS-CoV vaccines that the S protein on the surface of the virus is an ideal target for a vaccine. In SARS-CoV-1 and SARS-CoV-2, this protein interacts with the receptor ACE2, and antibodies targeting the spike can interfere with this binding, thereby neutralizing the virus. The structure of the S protein of SARS-CoV-2 was solved in record time at high resolution, contributing to our understanding of this vaccine target. More than 90 vaccines are being developed against SARS-CoV-2 by research teams in companies and universities across the world. |
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