SARS-CoV-2 ORF6 Peptide (IAEILLIIMRTFKVS)

Product Overview

• Article Name: SARS-CoV-2 ORF6 Peptide (IAEILLIIMRTFKVS)
• Biozol Catalog Number: ABT-VGP1156
• Supplier Catalog Number: VGP1156
• Alternative Catalog Number: ABT-VGP1156-100UG
• Manufacturer: Abcepta
• Category: Proteine/Peptide
• Alternative Names: , Accessory protein 6, Non-structural protein 6, ORF6 protein, Protein X3, ns6, sars-cov-2

Product Description

SARS-CoV-2 is part of the Coronaviridae family, whose members are named after their crown-like appearance under the electron microscope caused by the surface glycoproteins that decorate the virus. Coronaviruses have a large (30+ kb) single-stranded positivesense RNA genome encoding for several open reading frames. SARS-COV ORF6 protein is localized to the endoplasmic reticulum (ER)/Golgi membrane in infected cells, where it binds to and disrupts nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of STAT1 transport into the nucleus in response to interferon signaling, thus blocking the expression of STAT1-activated genes that establish an antiviral state.

Product Properties

• NCBI: 43740572
• UniProt: P0DTC6
• Form: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.