Pirtobrutinib (LOXO-305, LY 3527727, RXC-005) is a first-in-class, highly selective, non-covalent, next-generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells.Pirtobrutinibs selectivity for BTK more than 300 times more selective than other 370 kinases. Pirtobrutinib can be used in studies related to chronic lymphocytic leukemia (CLL).
Molecular Weight:
479.43
Purity:
99.94%
CAS Number:
[2101700-15-4]
Formula:
C22H21F4N5O3
Target:
BTK
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