IDH889 is an orally available, brain permeable, allosteric and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1). IDH889 showed high selectivity against IDH1R132 * mutant, with IC50 values of 0.02 µM, 0.072 µM and 1.38 µM against IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 showed high inhibition of intracellular 2-Hg level with IC50 value of 0.014 µM.
Molecular Weight:
436.48
Purity:
>98%
CAS Number:
[1429179-07-6]
Formula:
C23H25FN6O2
Target:
Isocitrate Dehydrogenase (IDH)
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