Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-kappaB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory.
Molecular Weight:
246.35
Purity:
>99%
CAS Number:
[6483-15-4]
Formula:
C15H22N2O
Target:
Autophagy
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