Onvansertib (PCM-075, NMS-1286937, NMS-P937) is a first-in-class, third-generation, oral, highly selective PLK1 inhibitor that induces tumor cell arrest in the G2/M phase and triggers apoptosis. It has a median IC50=136nM against a variety of CRC cell lines and inhibits xenograft models such as HT-29, HCT-116, and Colo-205 well.
Molecular Weight:
532.52
Purity:
>99%
CAS Number:
[1034616-18-6]
Formula:
C24H27F3N8O3
Target:
PLK
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