GNF4877 is a potent DYRK1A and GSK3beta inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased beta-cell proliferation (EC50 of 0.66 µM for mouse beta (R7T1) cells).
Molecular Weight:
494.52
Purity:
>99%
CAS Number:
[2041073-22-5]
Formula:
C25H27FN6O4
Target:
DYRK
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