Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect. Furthermore, Crebanine can inhibit the PI3K/Akt/mTOR pathway and generate reactive oxygen species, thereby blocking tumour proliferation and migration. In animal studies, Crebanine has also demonstrated central and peripheral analgesic and anti-inflammatory activity.
Molecular Weight:
339.39
Purity:
>99.0%
CAS Number:
[25127-29-1]
Formula:
C20H21NO4
Target:
Akt
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