AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRalpha, Tel-PDGFRbeta, V561D/D842V).
Molecular Weight:
479.51
Purity:
>99.0%
CAS Number:
[2248003-60-1]
Formula:
C24H26FN7O3
Target:
c-Kit
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