TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90alpha, HSP90beta, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 µmol/L).
Molecular Weight:
454.53
Purity:
>99%
CAS Number:
[1260533-36-5]
Formula:
C25H26N8O
Target:
HSP
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