PMX-53 is a potent CD88 (C5aR) antagonist with an IC50 of 20 nM, it inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation.
Molecular Weight:
896.09
Purity:
>99.0%
CAS Number:
[219639-75-5]
Formula:
C47H65N11O7
Target:
Complement System
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