RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36µM, 7.82µM and 13.86µM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome.
Molecular Weight:
462.89
Purity:
>99%
CAS Number:
[2784577-71-3]
Formula:
C24H19ClN4O4
Target:
RXFP
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