VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 30 pM to human MCL-1 in a TR-FRET assay. VU661013 destabilizes BIM/MCL1 association, leads to apoptosis in AML, and is active in venetoclax-resistant cells and xenografts.
Molecular Weight:
712.66
Purity:
>98.5%
CAS Number:
[2131184-57-9]
Formula:
C39H39Cl2N5O4
Target:
Bcl-2
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