Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain with IC50 of 74 nM. Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51.
Molecular Weight:
414.47
Purity:
>99%
CAS Number:
[2290527-07-8]
Formula:
C25H23FN4O
Target:
DNA/RNA Synthesis
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