Birinapant (TL32711) is a bivalent Smac analogue, which is a potent antagonist of XIAP and cIAP1 with Kd values of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces autoubiquitination and proteasome degradation of cIAP1 and cIAP2 in intact cells, resulting in the formation of RIPK1: Caspase-8 complex, which activates and induces tumor cell death.
Molecular Weight:
806.94
Purity:
99.63%
CAS Number:
[1260251-31-7]
Formula:
C42H56F2N8O6
Target:
IAP
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