Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. ED50 < 6.0 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells.
Purity:
>95%, Endotoxin < 0.2 EU/µg
CAS Number:
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Target:
Cytokines and Growth Factors
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