Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. Nutlin-3 induces apoptosis in cancer cells. Nutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 µM in cells with wild-type p53 such as HCT116, RKO and SJSA-1.
Molecular Weight:
581.49
Purity:
99.70%
CAS Number:
[548472-68-0]
Formula:
C30H30Cl2N4O4
Target:
Mdm2
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