Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.
Molecular Weight:
259.33
Purity:
99.62%
CAS Number:
[4311-88-0]
Formula:
C13H13N3OS
Target:
RIPK
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