Nofazinlimab (CS1003), which is a humanized IgG4 PD-1 mAb, bound to recombinant human, cynomolgus monkey, and mouse PD-1 with EC50 values of 0.1757, 0.2459, and 0.3664 nM, respectively. Nofazinlimab (CS1003)blocked PD-1 interaction with its ligands, dose-dependently enhanced T cell proliferation and secretion of cytokines (IL-2 and IFN-gamma) to the levels comparable to Pembrolizumab. Nofazinlimab can be used for unresectable hepatocellular carcinoma (uHCC) research.
Purity:
>98.0%
CAS Number:
[2377845-98-0]
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