Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 does not influence mTORC2 activity.
Molecular Weight:
578.3
Purity:
>99%
CAS Number:
[2216763-38-9]
Formula:
C25H19BrCl2N2O3S
Target:
mTOR
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