Siramesine (Lu 28-179) hydrochloride is an effective sigma-2 receptor agonist. Siramesine has a nanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and is 140 times more selective for sigma-2 receptors (IC50=17 nM). Siramesine has xC-system inhibitory activity associated with iron death.
Molecular Weight:
491.04
Purity:
>99.0%
CAS Number:
[224177-60-0]
Formula:
C30H32ClFN2O
Target:
Sigma Receptor
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