KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFbeta/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease.
Molecular Weight:
376.86
Purity:
99.0%
CAS Number:
[1118807-13-8]
Formula:
C18H17ClN2O3S
Target:
Others
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