PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies.
Molecular Weight:
467.34
Purity:
99.0%
CAS Number:
[1256565-36-2]
Formula:
C25H20Cl2N2O3
Target:
VEGFR/PDGFR
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