Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 µM. Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 µg/ml versus MIC 64 µg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 µM versus IC50 > 26 µM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd 10,000 nM).[1]
Molecular Weight:
382.48
Purity:
99.0%
CAS Number:
[1381289-58-2]
Formula:
C19H22N6OS
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