Pacritinib (SB1518) is an effective mutant inhibitor of wild-type JAK2 and JAK2V617F with IC50 of 23 nM and 19 nM, respectively. Pacritinib also inhibited FLT3 and its mutant FLT3D835Y with IC50 of 22 nM and 6 nM, respectively.
Molecular Weight:
472.58
Purity:
>99.5%
CAS Number:
[937272-79-2]
Formula:
C28H32N4O3
Target:
JAK
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