AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 µM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects.
Molecular Weight:
567.63
Purity:
99.0%
CAS Number:
[2241651-99-8]
Formula:
C34H31F2N3O3
Target:
Sodium Channel
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