PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 µM, DC50, 3.0 µM) and Mcl-1 (IC50, 11.81 µM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Molecular Weight:
941.84
Purity:
99.0%
CAS Number:
[2378801-85-3]
Formula:
C45H45BrN6O10S
Target:
PROTAC
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