SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells.
Molecular Weight:
322.3
Purity:
99.86%
CAS Number:
[895158-95-9]
Formula:
C16H11FN6O
Target:
IL Receptor/Related
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