NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCalpha. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure.
Molecular Weight:
207.23
Purity:
99.83%
CAS Number:
[64091-91-4]
Formula:
C10H13N3O2
Target:
Metabolite/Endogenous Metabolite
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