A-769662 is a potent, reversible AMPK activator with EC50of 0.8 µM, little effect on GPPase/FBPase activity. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 µM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 µM).
Molecular Weight:
360.39
Purity:
99.54%
CAS Number:
[844499-71-4]
Formula:
C20H12N2O3S
Target:
AMPK
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