AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases,
Molecular Weight:
621.08
Purity:
>99.0%
CAS Number:
[1050500-29-2]
Formula:
C24H18ClFN4O2
Target:
EGFR/HER2
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