Mk-886 (L 663536) is a potent, cellular permeable, orally active inhibitor of FLAP (IC50 at 30 nM) and leukotriene biosynthesis (IC50 at 3 nM and 1.1µM in whole white blood cells and human whole blood, respectively). Mk-886 is also a non-competitive PPARalpha antagonist that can induce apoptosis.
Molecular Weight:
472.08
Purity:
>98%
CAS Number:
[118414-82-7]
Formula:
C27H34ClNO2S
Target:
Lipoxygenase
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