Sophocarpine monohydrate is a HERG K+ channel blocker with IC50 of 100-300 µM and Na+ channel inward current inhibitor. Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-kappaB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration.
Molecular Weight:
264.36
Purity:
>99.0%
CAS Number:
[145572-44-7]
Formula:
C15H24N2O2
Target:
Autophagy
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