BI-4020 is a fourth-generation, orally active, non-covalent EGFR tyrosine kinase macrocyclic inhibitors (TKIs). It inhibits the triple mutant EGFR del19 T790M C797S mutant (IC50=0.2 nM in the BaF3 cell line), the double mutant EGFR del19 T790M, and the single mutant EGFR del19 (IC50=1 nM). and also retains activity against EGFR wt (IC50=190 nM), which can be used in studies related to non-small cell lung cancer (NSCLC).
Molecular Weight:
542.68
Purity:
>99.0%
CAS Number:
[2664214-60-0]
Formula:
C30H38N8O2
Target:
EGFR/HER2
* VAT and and shipping costs not included. Errors and price changes excepted
