Icotrokinra (JNJ-77242113, JNJ-2113) is a novel, orally active IL-23R peptide antagonist for studies related to plaque psoriasis. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNgamma and IL-17A in picomolar levels.
Molecular Weight:
1898.17
Purity:
99.22%
CAS Number:
[2763602-16-8]
Formula:
C90H120N20O22S2
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