Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D is a CYP2J3 inducer. By increasing the expression of CYP2J2/EETs and PPARalpha in human umbilical vein endothelial cells (HUVECs), Ophiopogonin D significantly inhibited Ang Ii-induced NF-kappaB nuclear translocation and IkappaBalpha down-regulation. Intracellular Ca2+ overload and activation of pro-inflammatory cytokines.
Molecular Weight:
855.02
Purity:
99.0%
CAS Number:
[945619-74-9]
Formula:
C44H70O16
Target:
PPAR
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