Terreic acid is a quinone epoxide antibiotic and a potent Btk inhibitor, blocking the interaction between PKC and the PH domain of Btk.T Terreic acid also acts on HMC-1 human mast cell lysates, inhibiting the binding of GST-BtkPH to PKC with an IC50 of approximately 100 µM. Terreic acid also acts on HMC-1 human mast cell lysates to inhibit the binding of GST-BtkPH to PKC, with an IC50 of approximately 100 µM. In addition, Terreic acid simultaneously reduces the percentage of senescent cells and SASP expression in cells exposed to stress stimuli.
Molecular Weight:
154.12
CAS Number:
[121-40-4]
Formula:
C7H6O4
Target:
Senolytics
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