Sovalleplenib is a potent, orally active, selective Syk inhibitor with an IC50 of 25 nM.Sovalleplenib inhibits tyrosine kinase-dependent Fcgamma receptor-mediated phagocytosis by macrophages, which in turn reduces phagocytotic destruction of platelets, as well as reduces production of antiplatelet antibodies by B-cells.Sovalleplenib has antitumor activity in immune thrombocytopenia (ITP).
Molecular Weight:
482.60
Purity:
>99.0%
CAS Number:
[1415792-84-5]
Formula:
C24H30N6O3S
Target:
Syk
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