NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. NCB-0846 blocks TGF-beta signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation.
Molecular Weight:
375.42
Purity:
100.00%
CAS Number:
[1792999-26-8]
Formula:
C21H21N5O2
Target:
TNIK
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