O4I3 is a potent and selective inhibitor of the KDM5A (JARID1A) isoform of H3K4 demethylase, with an IC50 value of 0.15 nM.O4I3 effectively induces OCT4 expression and enhances OSKM-induced pluripotent stem cell reprogramming efficiency (50 nM) of human primary fibroblasts by preventing KDM5A from interfering with the enrichment of H3K4Me3 on the OCT4 promoter. iPSC) reprogramming efficiency (50 nM).
Molecular Weight:
222.29
Purity:
>99.0%
CAS Number:
[88965-00-8]
Formula:
C15H14N2
Target:
Cell Culture
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