RMC-7977 is a highly selective, reversible, tri-complex RAS inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants. RMC-7977 demonstrated potent activity against RAS-addicted tumours carrying various RAS genotypes, particularly against cancer models with KRAS codon 12 mutations (KRASG12X).
Molecular Weight:
865.09
Purity:
>99.0%
CAS Number:
[2765082-12-8]
Formula:
C47H60N8O6S
Target:
Ras
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