BDE-47 is an apoptosis inducer involving ROS mediated mitochondrial pathway and Nrf2 pathway activation. BDE-47 reduced cell viability and disrupted mitochondrial dynamics by inhibiting mitochondrial fusion and fission simultaneously, leading to MMP decreases, ROS overgeneration, ATP depletion, and cellular disintegration in a dose-dependent manner.
Molecular Weight:
485.79
Purity:
97.0%
CAS Number:
[5436-43-1]
Formula:
C12H6Br4O
Target:
Apoptosis
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