RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-alpha and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury.
Purity:
>90%, Endotoxin < 1 EU/µg
CAS Number:
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Target:
Cytokines and Growth Factors
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