Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin-1 is a potent and selective PIKfyve inhibitor and inhibits late-stage autophagy by impairing lysosomal maturation.
Molecular Weight:
577.42
Purity:
>98.5%
CAS Number:
[351986-85-1]
Formula:
C26H24IN7O
Target:
Autophagy
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