A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation.
Molecular Weight:
275.34
Purity:
>99%
CAS Number:
[61413-54-5]
Formula:
C16H21NO3
Target:
PDE
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