Iberdomide (CC-220) is an orally effective cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 for cereblon binding affinity of approximately 150 nM. Iberdomide (CC-220) binds CRBN with higher affinity than lenalidomide and pomalidomide and has enhanced degradation of IKZF1 and IKZF3 with enhanced degradation.
Molecular Weight:
449.5
Purity:
>99.0%
CAS Number:
[1323403-33-3]
Formula:
C25H27N3O5
Target:
E1/E2/E3 Enzyme
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